Public health and service delivery programmes, interventions and policies (collectively,'
programmes') are typically developed and implemented for the primary purpose of effecting …

Clinical research attempts to address a relatively straightforward, and important challenge:
how do we determine whether one medical intervention is better than another, whether it …

Ethical guidelines for conducting clinical trials have historically been based on a perceived
therapeutic obligation to treat and benefit the patient-participants. The origins of this ethical …

Research ethics committees (RECs) are charged with providing an opinion on whether
research proposals are ethical. These committees are overseen by a central office that acts …

Abstract Is Institutional Review Board (IRB) approval and a rigorous informed consent
process enough? It is our view that this is no longer the case. Conventional research ethics …

This paper examines the UK's response to a recent European Clinical Trials Directive,
namely the Department of Health, Central Office for Research Ethics Committee guidance …

380 stronger protections for human research subjects in 2000.“There's more recognition that
research participants aren't just individuals, they are part of families and communities …

Research ethics has played a crucial part in health research (Israel 2016; Tolich 2016a;
Christians 2018; Gray 2018; Banks 2019; Portney 2020). Due to many abusive events in the …

Integrity and ethical issues play a role throughout all phases of clinical research. First,
policies and decisions that determine the research agenda, prioritizing some topics above …

Medical research involving human subjects raises complex ethical, legal and social issues.
Investigators sometimes find that their obligations with respect to a research project come …