The release of free fatty acids (FFAs) from adipocytes (ie lipolysis) is increased in obesity
and is a contributory factor to the development of insulin resistance. A recently identified …

Apelin is an adipokine secreted by adipocytes. Co-expression of apelin and apelin receptor
(APJ) in adipocytes implies the autocrine regulations of apelin on adipocyte functions …

Adipose tissue (AT) secretes several adipokines that influence insulin sensitivity and
potentially link obesity to insulin resistance. Apelin, a peptide present in different tissues, is …

The results presented herein demonstrate that apelin is expressed and secreted by both
human and mouse adipocytes. Apelin mRNA levels in isolated adipocytes are close to other …

Apelin is a peptide present in different cell types and secreted by adipocytes in humans and
rodents. Apelin exerts its effects through a G-protein-coupled receptor called APJ. During the …

Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling
protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans …

Recently, apelin was characterised as a novel adipose-expressed factor which is
upregulated in rodent and human obesity and influences cardiovascular function, as well as …

We have recently identified apelin as a novel adipokine up‐regulated by insulin and obesity.
Since obesity and insulin resistance are associated with chronically elevated levels of both …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

Apelin is a newly discovered peptide hormone that has recently been linked to insulin
resistance and obesity. Data collected from both the clinical and basic research settings …