Using a recently described serum-free culture system of purified human CD34+ progenitor
cells, we show here a critical cooperation of flt3 ligand (FL) with transforming growth factor …

Murine dendritic cells (DCs) can be classified into at least 2 subsets,“myeloid-
related”(CD11bbright, CD8α−) and “lymphoid-related”(CD11bdull, CD8α+), but the absolute …

Flt3 ligand (Flt3L) is a growth factor for hemopoietic progenitors and can promote the
expansion of both conventional dendritic cells (DCs) and plasmacytoid predendritic cells (p …

In this issue, two papers describe the in vitro generation of an intriguing subset of human
dendritic cells (DCs), the plasmacytoid DCs (pDCs [1, 2]). For nearly 20 years after their …

Current in vitro culture systems allow the generation of human dendritic cells (DCs), but the
output of mature cells remains modest. This contrasts with the extensive amplification of …

OBJECTIVE: Mechanisms of T-cell stimulation by Flt3 ligand (Flt3L) and granulocyte-
macrophage colony-stimulating factor (GM-CSF) remain unclear. Herein, we compared the …

Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early
hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact …

Dendritic cells (DCs) represent a family of ontogenically distinct leukocytes involved in
immune response regulation. The ability of DCs to stimulate T-cell immunity has led to their …

We established a humanized mouse model incorporating FLT3-ligand (FLT3-L)
administration after hematopoietic cell reconstitution to investigate expansion, phenotype …

Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are
important growth factors for dendritic cells (DC). Substantial numbers of DC can be …