Innate sensing of viral RNA analogs represents a promising tool for cancer intervention, yet
the tumor microenvironment (TME) renders tumor cells and immune cells unresponsive to …

Messenger RNA (mRNA) represents a promising next-generation approach for both
treatment and vaccination. Lipid based particles are one of the most investigated delivery …

There has been increased interest in the development of RNA-based vaccines for protection
against various infectious diseases and also for cancer immunotherapies. Rapid and cost …

The therapeutic potential for messenger RNA (mRNA) in infectious diseases and cancer
was first realized almost three decades ago, but only in 2018 did the first lipid nanoparticle …

Self-amplifying replicon RNA (RepRNA) are large molecules (12-14 kb); their self-replication
amplifies mRNA template numbers, affording several rounds of antigen production …

Messenger RNA (mRNA) vaccines have emerged as a flexible platform for vaccine
development. The evolution of lipid nanoparticles as effective delivery vehicles for modified …

The growing significance of messenger RNA (mRNA) therapeutics in diverse medical
applications, such as cancer, infectious diseases, and genetic disorders, highlighted the …

mRNA vaccines have recently proved to be highly effective against SARS-CoV-2. Key to
their success is the lipid-based nanoparticle (LNP), which enables efficient mRNA …

In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

Among the few available mRNA delivery vehicles, lipid nanoparticles (LNPs) are the most
clinically advanced but they require cumbersome four components and suffer from …