Comprehensive benchmarking and integration of tumor microenvironment cell estimation methods
Various computational approaches have been developed for estimating the relative
abundance of different cell types in the tumor microenvironment (TME) using bulk tumor …
abundance of different cell types in the tumor microenvironment (TME) using bulk tumor …
Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data
Immune cells infiltrating tumors can have important impact on tumor progression and
response to therapy. We present an efficient algorithm to simultaneously estimate the …
response to therapy. We present an efficient algorithm to simultaneously estimate the …
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Motivation The composition and density of immune cells in the tumor microenvironment
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression
E Becht, NA Giraldo, L Lacroix, B Buttard, N Elarouci… - Genome biology, 2016 - Springer
Abstract We introduce the Microenvironment Cell Populations-counter (MCP-counter)
method, which allows the robust quantification of the absolute abundance of eight immune …
method, which allows the robust quantification of the absolute abundance of eight immune …
Inferring tumour purity and stromal and immune cell admixture from expression data
K Yoshihara, M Shahmoradgoli, E Martínez… - Nature …, 2013 - nature.com
Infiltrating stromal and immune cells form the major fraction of normal cells in tumour tissue
and not only perturb the tumour signal in molecular studies but also have an important role …
and not only perturb the tumour signal in molecular studies but also have an important role …
Systematic assessment of tumor purity and its clinical implications
PURPOSE The tumor microenvironment is complex, comprising heterogeneous cellular
populations. As molecular profiles are frequently generated using bulk tissue sections, they …
populations. As molecular profiles are frequently generated using bulk tissue sections, they …
Quantitative analyses of the tumor microenvironment composition and orientation in the era of precision medicine
F Petitprez, CM Sun, L Lacroix… - Frontiers in …, 2018 - frontiersin.org
Tumors are formed by aggregates of cells of various origins including malignant, stromal
and immune cells. The number of therapies targeting the microenvironment is increasing as …
and immune cells. The number of therapies targeting the microenvironment is increasing as …
Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
M Schelker, S Feau, J Du, N Ranu, E Klipp… - Nature …, 2017 - nature.com
As interactions between the immune system and tumour cells are governed by a complex
network of cell–cell interactions, knowing the specific immune cell composition of a solid …
network of cell–cell interactions, knowing the specific immune cell composition of a solid …
New horizons in tumor microenvironment biology: challenges and opportunities
The tumor microenvironment (TME) is being increasingly recognized as a key factor in
multiple stages of disease progression, particularly local resistance, immune-escaping, and …
multiple stages of disease progression, particularly local resistance, immune-escaping, and …