Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

An intricate relationship between impaired immune functions and the age-related
accumulation of tissue senescent cells is rapidly emerging. The immune system is unique as …

Macrophage senescence, manifested by the special form of durable cell cycle arrest and
chronic low-grade inflammation like senescence-associated secretory phenotype, has long …

Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …

With aging, there is increased dysfunction of both innate and adaptive immune responses,
which contributes to impaired immune responses to pathogens and greater mortality and …

Answering these questions is a prerequisite for testing the hypothesis that clearance of
senescent macrophages can prolong lifespan/healthspan in animal models. So far, genetic …

Senescent cells (SCs) arise from normal cells in multiple organs due to inflammatory,
metabolic, DNA damage, or tissue damage signals. SCs are non-proliferating but …

Aging is a progressive degenerative process involving a chronic low-grade inflammation
and the accumulation of senescent cells. One major issue is to reveal the mechanisms …

Macrophages are key cells in innate and adaptive immune function. These cells are
involved in the destruction of bacteria, parasites, viruses and tumor cells and lead to the …

Chronic inflammation is the common pathological basis for such age-associated diseases
as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily …