Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis

CH Coles, N Mitakidis, P Zhang, J Elegheert… - Nature …, 2014 - nature.com
Receptor protein tyrosine phosphatase sigma (RPTPσ) regulates neuronal extension and
acts as a presynaptic nexus for multiple protein and proteoglycan interactions during …

Receptor protein tyrosine phosphatase sigma regulates synapse structure, function and plasticity

KE Horn, B Xu, D Gobert, BN Hamam… - Journal of …, 2012 - Wiley Online Library
J. Neurochem.(2012) 122, 147–161. Abstract The mechanisms that regulate synapse
formation and maintenance are incompletely understood. In particular, relatively few …

Mechanisms of PTPσ-mediated presynaptic differentiation

C Bomkamp, N Padmanabhan, B Karimi… - Frontiers in Synaptic …, 2019 - frontiersin.org
Formation of synapses between neurons depends in part on binding between axonal and
dendritic cell surface synaptic organizing proteins, which recruit components of the …

Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex

H Takahashi, P Arstikaitis, T Prasad, TE Bartlett… - Neuron, 2011 - cell.com
Neurotrophin receptor tyrosine kinases (Trks) have well-defined trophic roles in nervous
system development through kinase activation by neurotrophins. Yet Trks have typical cell …

Identification of novel binding sites for heparin in receptor protein-tyrosine phosphatase (RPTPσ): Implications for proteoglycan signaling

Y Katagiri, AA Morgan, P Yu, NJ Bangayan… - Journal of Biological …, 2018 - ASBMB
Receptor protein-tyrosine phosphatase RPTPσ has important functions in modulating neural
development and regeneration. Compelling evidence suggests that both heparan sulfate …

PTPσ drives excitatory presynaptic assembly via various extracellular and intracellular mechanisms

KA Han, JS Ko, G Pramanik, JY Kim… - Journal of …, 2018 - Soc Neuroscience
Leukocyte common antigen-receptor protein tyrosine phosphatases (LAR-RPTPs) are hub
proteins that organize excitatory and inhibitory synapse development through binding to …

Protein tyrosine phosphatase σ in proteoglycan-mediated neural regeneration regulation

PN Chien, SE Ryu - Molecular neurobiology, 2013 - Springer
The receptor-type protein tyrosine phosphatase PTPσ mediates neural development and
regeneration. Early studies on the ligands of PTPσ identified heparan sulfate proteolycan …

Dimerization of protein tyrosine phosphatase σ governs both ligand binding and isoform specificity

S Lee, C Faux, J Nixon, D Alete, J Chilton… - … and cellular biology, 2007 - Taylor & Francis
Signaling through receptor protein tyrosine phosphatases (RPTPs) can influence diverse
processes, including axon development, lymphocyte activation, and cell motility. The …

Orchestrating the synaptic network by tyrosine phosphorylation signalling

A Dabrowski, H Umemori - The journal of biochemistry, 2011 - academic.oup.com
The establishment of a functional brain requires coordinated and stereotyped formation of
synapses between neurons. For this, trans-synaptic molecular cues (synaptic organizers) …

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

SH Lim, SK Kwon, MK Lee, J Moon, DG Jeong… - The EMBO …, 2009 - embopress.org
The receptor‐type protein tyrosine phosphatases (RPTPs) have been linked to signal
transduction, cell adhesion, and neurite extension. PTPRT/RPTPρ is exclusively expressed …