Simple Summary Bone is an extremely metabolically active tissue that is regenerated and
repaired over its lifetime by bone remodeling. Most bone diseases are caused by abnormal …

The bones of the skeleton provide mechanical support for joints, tendons and ligaments,
protect vital organs from damage, and act as a reservoir for calcium and phosphate in the …

The bones of the skeleton provide mechanical support for joints, tendons and ligaments,
protect vital organs from damage, and act as a reservoir for calcium and phosphate in …

Bones have three major functions: to serve as mechanical support, sites of muscle insertion
and as a reserve of calcium and phosphate for the organism. Recently, a fourth function has …

Bone tissue is continuously remodeled through the concerted actions of bone cells, which
include bone resorption by osteoclasts and bone formation by osteoblasts, whereas …

This chapter is divided into three subsections: The bone biology part will provide some
insight into the matrix composition as well as the origin and basic function attributed to the …

Bone is organized in a hierarchical way that enables it to perform its mechanical,
metabolic/endocrine, hematopoietic, and protective functions. At the nanoscale level, the …

Publisher Summary The information and concepts described in this chapter form the basis
for understanding bone as a tissue and as an organ system. Bone is a mechanically …

The skeleton is a metabolically active organ that undergoes continuous remodeling
throughout life. This remodeling is necessary both to maintain the structural integrity of the …

Bone is a specialized connective tissue designed primarily to provide mechanical support. It
also plays a vital role in maintaining mineral homeostasis and hematopoiesis. This chapter …