Drug repurposing for antimicrobial discovery

MA Farha, ED Brown - Nature microbiology, 2019 - nature.com
Antimicrobial resistance continues to be a public threat on a global scale. The ongoing need
to develop new antimicrobial drugs that are effective against multi-drug-resistant pathogens …

Recent drug-repurposing-driven advances in the discovery of novel antibiotics

AK Konreddy, GU Rani, K Lee… - Current medicinal …, 2019 - ingentaconnect.com
Drug repurposing is a safe and successful pathway to speed up the novel drug discovery
and development processes compared with de novo drug discovery approaches. Drug …

Drug repurposing to overcome microbial resistance

J Jampilek - Drug Discovery Today, 2022 - Elsevier
Infections are a growing global threat, and the number of resistant species of microbial
pathogens is alarming. However, the rapid development of cross-resistant or multidrug …

Brief overview of approaches and challenges in new antibiotic development: a focus on drug repurposing

NK Boyd, C Teng, CR Frei - Frontiers in cellular and infection …, 2021 - frontiersin.org
Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative
to traditional drug discovery processes involving de novo synthesis. Drugs that are currently …

Drug repurposing as an alternative for the treatment of recalcitrant bacterial infections

A Rangel-Vega, LR Bernstein… - Frontiers in …, 2015 - frontiersin.org
Bacterial infection remains one of the leading causes of death worldwide, and the options for
treating such infections are decreasing, due the rise of antibiotic-resistant bacteria. The …

Drug repurposing for the treatment of bacterial and fungal infections

A Miró-Canturri, R Ayerbe-Algaba… - Frontiers in microbiology, 2019 - frontiersin.org
Multidrug-resistant (MDR) pathogens pose a well-recognized global health threat that
demands effective solutions; the situation is deemed a global priority by the World Health …

Drug repurposing screens and synergistic drug‐combinations for infectious diseases

W Zheng, W Sun, A Simeonov - British journal of pharmacology, 2018 - Wiley Online Library
Infectious diseases account for nearly one fifth of the worldwide death toll every year. The
continuous increase of drug‐resistant pathogens is a big challenge for treatment of …

[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

Drug repurposing to fight colistin and carbapenem-resistant bacteria

L Peyclit, SA Baron, JM Rolain - Frontiers in Cellular and Infection …, 2019 - frontiersin.org
The emergence of new resistance mechanisms, the failure of classical antibiotics in clinic,
the decrease in the development of antibiotics in the industry are all challenges that lead us …

Repurposing of antimicrobial agents for cancer therapy: what do we know?

C Pfab, L Schnobrich, S Eldnasoury, A Gessner… - Cancers, 2021 - mdpi.com
Simple Summary Despite the leaps and bounds in the prevention and treatment of cancer, it
remains the second leading cause of death worldwide. A significant hurdle during cancer …