The goal of this review is to describe barrier function of the intestine, the structure of the tight
junction, methods to evaluate intestinal permeability, and most importantly the relevance of …

This article discusses the concept of intestinal permeability and the barrier function of the
gut, elaborates on tight junction structure and the dynamic nature of its composition, outlines …

Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI)
tract. There is growing evidence that increases in intestinal permeability plays a pathogenic …

A major task of the intestine is to form a defensive barrier to prevent absorption of damaging
substances from the external environment. This protective function of the intestinal mucosa …

In the paper by Wapenaar et al (see page 463) the authors have taken a fascinating
approach to identifying shared mechanisms involved in the genesis of either coeliac disease …

An essential role of the intestinal epithelium is to separate luminal contents from the
interstitium, a function primarily determined by the integrity of the epithelium and the tight …

Intestinal epithelial barrier defects, or increased paracellular permeability, were first reported
in patients with Crohn's disease (CD) over 25 years ago. Although increased permeability …

The gastrointestinal tract constitutes one of the largest sites of exposure to the outside
environment. The function of the gastrointestinal tract in monitoring and sealing the host …

The intestinal barrier serves 2 critical functions for the survival of the individual: first, it allows
nutrient absorption and second, it defends the body from dangerous macromolecule …

The intestinal epithelial monolayer constitutes a physical and functional barrier between the
organism and the external environment. It regulates nutrients absorption, water and ion …