Sex-specific associations of testosterone and genetic factors with health span

X Zhao, S Liang, N Wang, T Hong… - Frontiers in …, 2021 - frontiersin.org
Background Previous studies have suggested associations between testosterone, genetic
factors, and a series of complex diseases, but the associations with the lifespan phenotype …

Genetic analyses implicate complex links between adult testosterone levels and health and disease

JT Leinonen, N Mars, LE Lehtonen… - Communications …, 2023 - nature.com
Background Testosterone levels are linked with diverse characteristics of human health, yet,
whether these associations reflect correlation or causation remains debated. Here, we …

Genetic determinants of serum testosterone concentrations in men

C Ohlsson, H Wallaschofski, KL Lunetta, L Stolk… - PLoS …, 2011 - journals.plos.org
Testosterone concentrations in men are associated with cardiovascular morbidity,
osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of …

Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES …

DS Lopez, W Wulaningsih, KK Tsilidis, J Baillargeon… - Hormones, 2020 - Springer
Purpose Testosterone (T) plays an important role in men's health and its deficiency is linked
with poorer health. However, the role of nutritional and lifestyle factors in T regulation and …

Association of genetically determined chronotype with circulating testosterone: a Mendelian randomization study

T Ichikawa, T Kobayashi, T Hachiya… - Frontiers in …, 2024 - frontiersin.org
Low testosterone levels in men have been linked to decreased physical and mental function,
as well as a reduced quality of life. Previous prospective observational studies have …

[HTML][HTML] Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study

B Zhao, Z Wang, D Liu, S Zhang - Frontiers in Endocrinology, 2023 - frontiersin.org
Background Testosterone plays a key role in women, but the associations of serum
testosterone level with gynecological disorders risk are inconclusive in observational …

[HTML][HTML] Testosterone, risk, and socioeconomic position in British men: Exploring causal directionality

A Hughes, M Kumari - Social Science & Medicine, 2019 - Elsevier
Lower testosterone levels in men are observationally associated with worse health, but it is
unclear whether they contribute to well-established social gradients in health. Mendelian …

Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank

S Harrison, NM Davies, LD Howe, A Hughes - Science Advances, 2021 - science.org
Men with more advantaged socioeconomic position (SEP) have been observed to have
higher levels of testosterone. It is unclear whether these associations arise because …

Clinical benefits and adverse effects of genetically-elevated free testosterone levels: a mendelian randomization analysis

P Mohammadi-Shemirani, M Chong, M Pigeyre… - medRxiv, 2019 - medrxiv.org
ABSTRACT BACKGROUND Testosterone products are increasingly being prescribed to
males for a variety of possible health benefits but the causal relationship between …

Testosterone: Relationships with Metabolic Disorders in Men—An Observational Study from SPECT‐China

J Cheng, B Han, Q Li, F Xia, H Zhai… - International journal …, 2017 - Wiley Online Library
Background. The strength of associations between total testosterone (TT) and metabolic
parameters may vary in different nature of population structure; however, no study has ever …