Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory

E Santini, RU Muller, GJ Quirk - Journal of Neuroscience, 2001 - Soc Neuroscience
Extinction of conditioned fear to a tone paired with foot shock is thought to involve the
formation of new memory. In support of this, previous studies have shown that extinction of …

Reconsolidation and extinction of conditioned fear: inhibition and potentiation

JLC Lee, AL Milton, BJ Everitt - Journal of Neuroscience, 2006 - Soc Neuroscience
NMDA receptors are important for the acquisition, reconsolidation, and extinction of
memories. NMDA receptor antagonists impair these memory processes, whereas the partial …

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

R Kalisch, B Holt, P Petrovic, B De Martino… - Cerebral …, 2009 - academic.oup.com
Animal research suggests that the consolidation of fear and extinction memories depends
on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and …

Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace

SC Mao, YH Hsiao, PW Gean - Journal of Neuroscience, 2006 - Soc Neuroscience
Much evidence indicates that extinction training does not erase memory traces but instead
forms inhibitory learning that prevents the expression of original memory. Fear conditioning …

[HTML][HTML] Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex

A Burgos-Robles, I Vidal-Gonzalez, E Santini, GJ Quirk - Neuron, 2007 - cell.com
Extinction of conditioned fear is an active learning process requiring N-methyl-D-aspartate
receptors (NMDARs), but the timing, location, and neural mechanisms of NMDAR-mediated …

The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat

JM Langton, JH Kim, J Nicholas… - Learning & …, 2007 - learnmem.cshlp.org
Recent findings reveal qualitative developmental differences in extinction of learned fear.
The present study explored potential developmental differences in the role of NMDA in …

Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors

K Zushida, M Sakurai, K Wada… - Journal of …, 2007 - Soc Neuroscience
Contextual fear memory is attenuated by the re-exposure of mice to the context without
aversive stimulus. This phenomenon is called extinction. Here, we report that a potentiator of …

Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats

H Lee, JJ Kim - Journal of Neuroscience, 1998 - Soc Neuroscience
NMDA receptors in the amygdala seem to be critical for fear conditioning in naive rats.
Recent spatial-learning studies suggest that previous learning protected animals from the …

Dorsal hippocampus and classical fear conditioning to tone and context in rats: Effects of local NMDA‐receptor blockade and stimulation

T Bast, WN Zhang, J Feldon - Hippocampus, 2003 - Wiley Online Library
Consistent with the importance of the hippocampus in learning more complex stimulus
relations, but not in simple associative learning, the dorsal hippocampus has commonly …

The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear

V Laurent, AR Marchand, RF Westbrook - Learning & memory, 2008 - learnmem.cshlp.org
Extinction of conditioned fear involves new learning that inhibits but does not eliminate the
original fear memory. This inhibitory learning is thought to require activation of NMDA …