Antibiotic-resistant infections pose multiple challenges to healthcare systems, contributing to
higher mortality, morbidity, and escalating cost. Clinicians must regularly make rapid …

Mutation acquisition is a major mechanism of bacterial antibiotic resistance that remains
insufficiently characterised. Here we present RM-seq, a new amplicon-based deep …

Breaking the code of antibiotic resistance | Nature Reviews Microbiology Skip to main content
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According to the World Health Organization,“Antimicrobial resistance… threatens the
effective prevention and treatment of an ever-increasing range of infections caused by …

Bacterial infections and antimicrobial resistance are a major cause for morbidity and
mortality worldwide. Antimicrobial resistance often arises from antimicrobial misuse, where …

Bloodstream infections are associated with high mortality rates because of the probable
manifestation of sepsis, severe sepsis and septic shock1. Therefore, rapid administration of …

Whole genome sequencing (WGS) is increasingly advocated as a diagnostic tool to identify
the cause (s) of infection and/or drug resistance1. With rapid advances in sequencing …

Detailed knowledge on how bacteria evade antibiotics and eventually develop resistance
could open avenues for novel therapeutics and diagnostics. It is thereby key to develop a …

Objectives Identification of antimicrobial resistance genes is important for understanding the
underlying mechanisms and the epidemiology of antimicrobial resistance. As the costs of …

Background Development of drug resistance in bacteria causes antibiotic therapies to be
less effective and more costly. Moreover, our understanding of the process remains …