Fibrosis is known as the final common endpoint of chronic inflammation and failure of tissue
repair. In the liver, this endpoint of fibrosis and scarring throughout the organ is unresolvable …

Introduction Conclusion 1 2 3 4 Page 1 Biliary2023 Scan to download the poster Introduction •
Biliary fibrosis can be slowed but not ameliorated, transplantation is the only solution,. • …

Currently there are no effective antifibrotic therapies for liver cirrhosis, a major killer
worldwide. To obtain a cellular resolution of directly-relevant pathogenesis and to inform …

Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet
patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified …

Liver fibrosis is a major cause of death worldwide. As a progressive step in chronic liver
disease, fibrosis is almost always diagnosed too late with limited treatment options. Here, we …

Single cell and spatially resolved 'omic'techniques have enabled deep characterization of
clinical pathologies that remain poorly understood, providing unprecedented insights into …

Liver fibrosis is the excessive accumulation of extracellular matrix that can progress to
cirrhosis and failure if untreated. The mechanisms of fibrogenesis are multi-faceted and …

Background Biliary atresia (BA) is a devastating inflammatory and fibrosing cholangiopathy
of neonates with unknown aetiology. We aim to investigate the relationship between these …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …

Single-cell RNA sequencing (scRNA-seq) has advanced our understanding of cell types
and their heterogeneity within the human liver, but the spatial organization at single-cell …