[HTML][HTML] TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells
S Asuthkar, KK Velpula, PA Elustondo… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The cold and menthol receptor TRPM8 is highly expressed in prostate and prostate cancer
(PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The …
(PC). Recently, we identified that TRPM8 is as an ionotropic testosterone receptor. The …
[HTML][HTML] High-throughput proteome analysis reveals targeted TRPM8 degradation in prostate cancer
The Ca 2+-permeable ion channel TRPM8 is a hallmark of the prostate epithelium. We
recently discovered that TRPM8 is an ionotropic testosterone receptor. This finding …
recently discovered that TRPM8 is an ionotropic testosterone receptor. This finding …
[HTML][HTML] Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement
TRPM8 (melastatine-related transient receptor potential member 8), a member of the
transient receptor potential (TRP) superfamily of cation channels, has been shown to be a …
transient receptor potential (TRP) superfamily of cation channels, has been shown to be a …
[HTML][HTML] TRPM8 protein expression in hormone naïve local and lymph node metastatic prostate cancer
A Lunardi, M Barbareschi, FG Carbone, L Morelli… - Pathologica, 2021 - ncbi.nlm.nih.gov
Objective Prostate cancer (PCa) is the second most common malignancy in men.
Radiotherapy and surgery successfully control organ-confined tumors, although, locally …
Radiotherapy and surgery successfully control organ-confined tumors, although, locally …
Pharmacological and functional properties of TRPM8 channels in prostate tumor cells
M Valero, C Morenilla-Palao, C Belmonte… - Pflügers Archiv-European …, 2011 - Springer
Prostate cancer (PC) is a major health problem in adult males. TRPM8, a cationic TRP
channel activated by cooling and menthol is upregulated in PC. However, the precise role of …
channel activated by cooling and menthol is upregulated in PC. However, the precise role of …
[HTML][HTML] TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function?
L Zhang, GJ Barritt - Endocrine-related cancer, 2006 - erc.bioscientifica.com
During the past 5 years it has emerged that the transient receptor potential (TRP) family of
Ca 2+-and Na+-permeable channels plays a diverse and important role in cell biology and …
Ca 2+-and Na+-permeable channels plays a diverse and important role in cell biology and …
PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression
Although the transient receptor potential melastatin 8 (TRPM8) cold receptor is highly
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
expressed in prostate cancer (PCa) and constitutes a promising diagnostic and prognostic …
[HTML][HTML] Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells
Since its cloning a decade ago, TRPM8 channel has emerged as a promising prognostic
marker and a putative therapeutic target in prostate cancer (PCa). However, recent studies …
marker and a putative therapeutic target in prostate cancer (PCa). However, recent studies …
[HTML][HTML] TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration
GP Grolez, DV Gordiendko, M Clarisse… - Cell death & …, 2019 - nature.com
In prostate carcinogenesis, androgens are known to control the expression of the transient
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …
receptor potential melastatin 8 (TRPM8) protein via activation of androgen receptor (AR) …
Carvacrol alleviates prostate cancer cell proliferation, migration, and invasion through regulation of PI3K/Akt and MAPK signaling pathways
Y Luo, JY Wu, MH Lu, Z Shi, N Na… - Oxidative medicine and …, 2016 - Wiley Online Library
TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we
investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation …
investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation …