Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis

H MotieGhader, E Safavi, A Rezapour, FF Amoodizaj… - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness.
This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS …

Repurposing novel therapeutic candidate drugs for coronavirus disease-19 based on protein-protein interaction network analysis

M Adhami, B Sadeghi, A Rezapour, AA Haghdoost… - BMC …, 2021 - Springer
Background The coronavirus disease-19 (COVID-19) emerged in Wuhan, China and rapidly
spread worldwide. Researchers are trying to find a way to treat this disease as soon as …

[HTML][HTML] Network bioinformatics analysis provides insight into drug repurposing for COVID-19

X Li, J Yu, Z Zhang, J Ren, AE Peluffo, W Zhang… - Medicine in Drug …, 2021 - Elsevier
The COVID-19 disease caused by the SARS-CoV-2 virus is a health crisis worldwide. While
developing novel drugs and vaccines is long, repurposing existing drugs against COVID-19 …

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposing

P Krishnamoorthy, AS Raj, S Roy, NS Kumar… - Computers in biology …, 2021 - Elsevier
The ongoing COVID-19 pandemic caused by the coronavirus, SARS-CoV-2, has already
caused in excess of 1.25 million deaths worldwide, and the number is increasing …

Host transcriptome-guided drug repurposing for COVID-19 treatment: a meta-analysis based approach

T Loganathan, S Ramachandran, P Shankaran… - PeerJ, 2020 - peerj.com
Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health …

A connectivity map-based drug repurposing study and integrative analysis of transcriptomic profiling of SARS-CoV-2 infection

SZ Mousavi, M Rahmanian, A Sami - Infection, Genetics and Evolution, 2020 - Elsevier
Aims The recent outbreak of COVID-19 has become a global health concern. There are
currently no effective treatment strategies and vaccines for the treatment or prevention of this …

DTSEA: a network-based drug target set enrichment analysis method for drug repurposing against COVID-19

Y Su, J Wu, X Li, J Li, X Zhao, B Pan, J Huang… - Computers in Biology …, 2023 - Elsevier
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic is still wreaking havoc
worldwide. Therefore, the urgent need for efficient treatments pushes researchers and …

In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential …

A Lopez-Cortes, P Guevara-Ramirez… - Frontiers in …, 2021 - frontiersin.org
Background: There is pressing urgency to identify therapeutic targets and drugs that allow
treating COVID-19 patients effectively. Methods: We performed in silico analyses of immune …

[HTML][HTML] In silico drug repurposing to combat COVID-19 based on pharmacogenomics of patient transcriptomic data

S Das, K Camphausen, U Shankavaram - Research square, 2020 - ncbi.nlm.nih.gov
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) continues to affect a
growing number of populations in different parts of the world. In the current situation, drug …

Drug repurposing for COVID-19 treatment by integrating network pharmacology and transcriptomics

DY Liu, JC Liu, S Liang, XH Meng, J Greenbaum… - Pharmaceutics, 2021 - mdpi.com
Since coronavirus disease 2019 (COVID-19) is a serious new worldwide public health crisis
with significant morbidity and mortality, effective therapeutic treatments are urgently needed …