Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

X Lin, B Fu, Y Xiong, N Xing, W Xue, D Guo… - PLoS …, 2023 - journals.plos.org
Coronavirus disease 2019 is a respiratory infectious disease caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Evidence on the pathogenesis of SARS …

Secreted ORF8 is a pathogenic cause of severe COVID-19 and is potentially targetable with select NLRP3 inhibitors

X Wu, MK Manske, GJ Ruan, TL Witter… - BioRxiv, 2021 - biorxiv.org
ABSTRACT COVID-19 is a significant cause of morbidity and mortality in blood cancer
patients, especially those on immunosuppressive therapy. Despite extensive research, the …

SARS-CoV-2 ORF8 forms intracellular aggregates and inhibits IFNγ-induced antiviral gene expression in human lung epithelial cells

H Geng, S Subramanian, L Wu, HF Bu… - Frontiers in …, 2021 - frontiersin.org
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
COVID-19, a disease that involves significant lung tissue damage. How SARS-CoV-2 …

SARS-CoV-2 ORF6 protein does not antagonize interferon signaling in respiratory epithelial Calu-3 cells during infection

M Li, K Ayyanathan, M Dittmar, J Miller, I Tapescu… - Mbio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths, posing a substantial threat to global public health. Viruses evolve different strategies …

Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages

N Kriplani, S Clohisey, S Fonseca, S Fletcher, HM Lee… - bioRxiv, 2021 - biorxiv.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still adapting to its new
human host. Attention has focussed on the viral spike protein, but substantial variation has …

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

M Kohyama, T Suzuki, W Nakai, C Ono… - International …, 2023 - academic.oup.com
Many patients with severe COVID-19 suffer from pneumonia and the elucidation of the
mechanisms underlying the development of this severe condition is important. The in vivo …

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression

ME McGrath, Y Xue, L Taylor, C Dillen… - PLoS …, 2024 - journals.plos.org
The virus severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, is the causative
agent of the current COVID-19 pandemic. It possesses a large 30 kilobase (kb) genome that …

Glycosylated, Lipid-Binding, CDR-Like Domains of SARS-CoV-2 ORF8 Indicate Unique Sites of Immune Regulation

F Wu, X Chen, Y Ma, Y Wu, R Li, Y Huang… - Microbiology …, 2023 - Am Soc Microbiol
The outbreak of the novel coronavirus SARS-CoV-2 has posed a significant threat to human
health and the global economy since the end of 2019. Unfortunately, due to the virus's rapid …

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

K Matsuoka, N Imahashi, M Ohno, H Ode… - Journal of Biological …, 2022 - ASBMB
ORF8 is an accessory protein encoded by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2). Consensus regarding the biological functions of ORF8 is lacking, largely …

Endoplasmic reticulum-associated SARS-CoV-2 ORF3a elicits heightened cytopathic effects despite robust ER-associated degradation

J Zhang, R Cruz-Cosme, C Zhang, D Liu, Q Tang… - Mbio, 2024 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF3a protein plays a vital
role in viral pathogenesis and coronavirus disease 2019 (COVID-19). Like the spike protein …