The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

Y Ren, T Shu, DI Wu, J Mu, C Wang, M Huang… - Cellular & molecular …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the ongoing
pandemic of Coronavirus Disease 2019. SARS-CoV-2 belongs to the genus …

Loss of orf3b in the circulating SARS-CoV-2 strains

JY Lam, CK Yuen, JD Ip, WM Wong… - Emerging microbes & …, 2020 - Taylor & Francis
The newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since
December 2019 with more than 35 million laboratory confirmed human infections and over …

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Y Zhang, Y Chen, Y Li, F Huang… - Proceedings of the …, 2021 - National Acad Sciences
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has
become a global pandemic and has claimed over 2 million lives worldwide. Although the …

Severe acute respiratory syndrome coronavirus 2 ORF8 protein inhibits type I interferon production by targeting HSP90B1 signaling

J Chen, Z Lu, X Yang, Y Zhou, J Gao… - Frontiers in cellular …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a global pandemic that has currently infected over 430 …

SARS-CoV-2 ORF7b: is a bat virus protein homologue a major cause of COVID-19 symptoms?

ML Fogeron, R Montserret, J Zehnder, MH Nguyen… - BiorXiV, 2021 - biorxiv.org
ORF7b is an accessory protein of SARS-CoV-2, the virus behind the COVID-19 pandemic.
Using cell-free synthesized ORF7b, we experimentally show that ORF7b assembles into …

The functional classification of ORF8 in SARS-CoV-2 replication, immune evasion, and viral pathogenesis inferred through phylogenetic profiling

M Fahmi, H Kitagawa, G Yasui… - Evolutionary …, 2021 - journals.sagepub.com
ORF8 is a highly variable genomic region of SARS-CoV-2. Although non-essential and the
precise functions are unknown, it has been suggested that this protein assists in SARS-CoV …

SARS-CoV-2 and ORF3a: Non-synonymous mutations and polyproline regions

E Issa, G Merhi, B Panossian, T Salloum, S Tokajian - bioRxiv, 2020 - biorxiv.org
The effect of the rapid accumulation of non-synonymous mutations on the pathogenesis of
SARS-CoV-2 is not yet known. To predict the impact of non-synonymous mutations and …

SARS-CoV-2 ORF8 mediates signals in macrophages and monocytes through MyD88 independently of the IL-17 receptor

NO Ponde, KE Shoger, MS Khatun… - The Journal of …, 2023 - journals.aai.org
SARS-CoV-2 has caused an estimated 7 million deaths worldwide to date. A secreted SARS-
CoV-2 accessory protein, known as open reading frame 8 (ORF8), elicits inflammatory …

Discovery and genomic characterization of a 382-nucleotide deletion in ORF7b and ORF8 during the early evolution of SARS-CoV-2

YCF Su, DE Anderson, BE Young, M Linster, F Zhu… - MBio, 2020 - Am Soc Microbiol
To date, limited genetic changes in the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) genome have been described. Here, we report a 382-nucleotide (nt) deletion …

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

TG Flower, CZ Buffalo, RM Hooy… - Proceedings of the …, 2021 - National Acad Sciences
The molecular basis for the severity and rapid spread of the COVID-19 disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. ORF8 …