Anticoagulants are the cornerstone for prevention and treatment of thrombosis but are not
completely effective, and concerns about the risk of bleeding continue to limit their uptake …

The goal of anticoagulant therapy is to attenuate thrombosis without compromising
hemostasis. Although the direct oral anticoagulants are associated with less intracranial …

Introduction: Anticoagulation without bleeding is an ideal goal in treating thrombosis,
however, this goal has not been achieved. All current anticoagulants are associated with …

Therapeutic anticoagulation is indicated for a variety of circumstances and conditions in
several fields of medicine to prevent or treat venous and arterial thromboembolism …

Despite advances in anticoagulant therapy, thrombosis remains the leading cause of
morbidity and mortality worldwide. Heparin and vitamin K antagonists (VKAs), the first …

Hemostasis and thrombosis are believed to be so intricately linked that any strategies that
reduce thrombosis will have an inevitable impact on hemostasis. Consequently, bleeding is …

Although the non-vitamin antagonist oral anticoagulants produce less intracranial bleeding
than warfarin, serious bleeding still occurs. Therefore, the search for safer anticoagulants …

Anticoagulant drugs that are currently used to prevent and/or treat thrombosis have some
limitations that hinder their ability to meet specific clinical requirements. While these drugs …

Background Phase II randomized controlled trials (RCTs) on factor (F) XI inhibitors have
shown promising results but they were burdened by low statistical power for clinical …

Despite major advancements in the development of safer and more effective anticoagulant
agents, bleeding complications remain a significant concern in the treatment of …