Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

TJ Nowakowski, A Bhaduri, AA Pollen, B Alvarado… - Science, 2017 - science.org
Systematic analyses of spatiotemporal gene expression trajectories during organogenesis
have been challenging because diverse cell types at different stages of maturation and …

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

UC Eze, A Bhaduri, M Haeussler, TJ Nowakowski… - Nature …, 2021 - nature.com
The human cortex comprises diverse cell types that emerge from an initially uniform
neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To …

An atlas of cortical arealization identifies dynamic molecular signatures

A Bhaduri, C Sandoval-Espinosa, M Otero-Garcia, I Oh… - Nature, 2021 - nature.com
The human brain is subdivided into distinct anatomical structures, including the neocortex,
which in turn encompasses dozens of distinct specialized cortical areas. Early …

Single-cell analysis of prenatal and postnatal human cortical development

D Velmeshev, Y Perez, Z Yan, JE Valencia… - Science, 2023 - science.org
We analyzed> 700,000 single-nucleus RNA sequencing profiles from 106 donors during
prenatal and postnatal developmental stages and identified lineage-specific programs that …

Chromatin accessibility dynamics in a model of human forebrain development

AE Trevino, N Sinnott-Armstrong, J Andersen, SJ Yoon… - Science, 2020 - science.org
INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …

Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development

X Fan, Y Fu, X Zhou, L Sun, M Yang, M Wang… - Science …, 2020 - science.org
Neurogenesis processes differ in different areas of the cortex in many species, including
humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and …

Molecular programs of regional specification and neural stem cell fate progression in macaque telencephalon

N Micali, S Ma, M Li, SK Kim, X Mato-Blanco… - Science, 2023 - science.org
During early telencephalic development, intricate processes of regional patterning and
neural stem cell (NSC) fate specification take place. However, our understanding of these …

Molecular logic of cellular diversification in the mouse cerebral cortex

DJ Di Bella, E Habibi, RR Stickels, G Scalia, J Brown… - Nature, 2021 - nature.com
The mammalian cerebral cortex has an unparalleled diversity of cell types, which are
generated during development through a series of temporally orchestrated events that are …

Spatiotemporal molecular dynamics of the developing human thalamus

CN Kim, D Shin, A Wang, TJ Nowakowski - Science, 2023 - science.org
The thalamus plays a central coordinating role in the brain. Thalamic neurons are organized
into spatially distinct nuclei, but the molecular architecture of thalamic development is poorly …

Comprehensive cell atlas of the first-trimester developing human brain

E Braun, M Danan-Gotthold, LE Borm, KW Lee… - Science, 2023 - science.org
The adult human brain comprises more than a thousand distinct neuronal and glial cell
types, a diversity that emerges during early brain development. To reveal the precise …