The effect of alcoholism on salsolinol and biogenic amines in human brain

B Sjöquist, E Perdahl, B Winblad - Drug and alcohol dependence, 1983 - Elsevier
Chronic alcoholics with a well documented history of alcohol abuse were divided at autopsy
into two groups, intoxicated alcoholics (IA, with blood ethanol levels) and sober alcoholics …

A systematic regional study of brain salsolinol levels during and immediately following chronic ethanol ingestion in rats

K Matsubara, S Fukushima, Y Fukui - Brain research, 1987 - Elsevier
Regional contents of salsolinol and catecholamines in the brain of normal and ethanol-
treated rats were studied. Male Sprague-Dawley rats were given ethanol solution as sole …

Increased salsolinol levels in rat striatum and limbic forebrain following chronic ethanol treatment

B Sjöquist, S Liljequist, J Engel - Journal of Neurochemistry, 1982 - Wiley Online Library
Endogenous levels of salsolinol and its methylated metabolite were measured by combined
gas chromatography and mass spectrometry in rats chronically exposed to ethanol for 150 …

In vivo study of salsolinol produced by a high concentration of acetaldehyde in the striatum and nucleus accumbens of free‐moving rats

M Jamal, K Ameno, S Ameno… - Alcoholism: Clinical …, 2003 - Wiley Online Library
Background: Salsolinol, a neuropharmacologically active compound, is formed by the
condensation of acetaldehyde (AcH) with dopamine (DA) in the brain. The aim of our study …

The role of salsolinol in alcohol intake and withdrawal.

A Clow, A Topham, JB Saunders, R Murray… - Progress in clinical …, 1985 - europepmc.org
We studied the urinary excretion of the tetrahydroisoquinoline (TIQ) salsolinol, formed from
acetaldehyde and dopamine, in both severely and moderately dependent alcoholics during …

Elevation of plasma salsolinol sulfate in chronic alcoholics as compared to nonalcoholics

BA Faraj, VM Camp, DC Davis… - Alcoholism: Clinical …, 1989 - Wiley Online Library
This report describes a radioenzymatic assay for the measurement of salsolinol and
dopamine sulfate levels in plasma. It is based on a sulfatase‐catalyzed hydrolysis of the …

The influences of ethanol and other factors on the excretion of urinary salsolinol in social drinkers

M Hirst, DR Evans, CW Gowdey, MA Adams - … Biochemistry and Behavior, 1985 - Elsevier
Salsolinol, a substance that may participate in the development of alcoholism, has been
identified in urine and other biological samples from alcoholics. Differentials have been …

Dopamine and salsolinol levels in rat hypothalami and striatum after schedule-induced self-injection (SISI) of ethanol and acetaldehyde

WD Myers, KT Ng, G Singer, GA Smythe, MW Duncan - Brain research, 1985 - Elsevier
Endogenous levels of salsolinol and dopamine were measured by a gas
chromatography/mass spectrometry (GC/MS)—selected ion monitoring technique using …

A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats

J Lee, VA Ramchandani, K Hamazaki… - Alcoholism: Clinical …, 2010 - Wiley Online Library
Background:(R/S)‐Salsolinol (SAL), a condensation product of dopamine (DA) with
acetaldehyde, has been speculated to have a role in the etiology of alcoholism. Earlier …

IN VIVO FORMATION OF SALSOLINOL INDUCED BY HIGH ACETALDEHYDE CONCENTRATION IN RAT STRIATUM EMPLOYING MICRODIALYSIS

M Jamal, K Ameno, T Kubota, S Ameno… - Alcohol and …, 2003 - academic.oup.com
Aims: The in vivo formation of salsolinol (1-methyl-6, 7-dihydroxy-1, 2, 3, 4-
tetrahydroisoquionoline), an endogeneous condensation product of dopamine (DA) with …