miRNA 146a-5p-loaded poly(d,l-lactic-co-glycolic acid) nanoparticles impair pain behaviors by inhibiting multiple inflammatory pathways in microglia
TL Phạm, Y Yin, HH Kwon, N Shin, SI Kim, H Park… - …, 2020 - Taylor & Francis
Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can
attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic …
attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic …
p38 siRNA-encapsulated PLGA nanoparticles alleviate neuropathic pain behavior in rats by inhibiting microglia activation
Aim: To investigate whether p38 small-interfering RNA-loaded nanoparticles (p38 siRNA
NPs) attenuate spinal nerve ligation (SNL)-induced neuropathic pain in rats by suppressing …
NPs) attenuate spinal nerve ligation (SNL)-induced neuropathic pain in rats by suppressing …
CX3CR1-targeted PLGA nanoparticles reduce microglia activation and pain behavior in rats with spinal nerve ligation
C Noh, HJ Shin, S Lee, SI Kim, YH Kim… - International Journal of …, 2020 - mdpi.com
Activation of CX3CR1 in microglia plays an important role in the development of neuropathic
pain. Here, we investigated whether neuropathic pain could be attenuated in spinal nerve …
pain. Here, we investigated whether neuropathic pain could be attenuated in spinal nerve …
[HTML][HTML] Down-regulation of miRNA-128 contributes to neuropathic pain following spinal cord injury via activation of P38
Z Yang, J Xu, R Zhu, L Liu - Medical science monitor: international …, 2017 - ncbi.nlm.nih.gov
Background Neuropathic pain (NPP) arises from a lesion or dysfunction of the
somatosensory nervous system. Recent studies have demonstrated multiple microRNAs …
somatosensory nervous system. Recent studies have demonstrated multiple microRNAs …
Knockdown of miR-130a-3p alleviates spinal cord injury induced neuropathic pain by activating IGF-1/IGF-1R pathway
L Yao, Y Guo, L Wang, G Li, X Qian, J Zhang… - Journal of …, 2021 - Elsevier
Background Recent studies have elucidated the instrumental role of microRNAs (miRNAs)
in neuropathic pain (NP) progression. As one member of miRNAs, miR-130a-3p has been …
in neuropathic pain (NP) progression. As one member of miRNAs, miR-130a-3p has been …
miR-185-5p alleviates CCI-induced neuropathic pain by repressing NLRP3 inflammasome through dual targeting MyD88 and CXCR4
A Huang, L Ji, Y Huang, Q Yu, Y Li - International Immunopharmacology, 2022 - Elsevier
MicroRNAs (miRNAs) are important modulators in the evolvement and progression of
neuropathic pain (NP). According to reports, miR-185-5p contributes to various diseases …
neuropathic pain (NP). According to reports, miR-185-5p contributes to various diseases …
miR‐223 Inhibits the Polarization and Recruitment of Macrophages via NLRP3/IL‐1β Pathway to Meliorate Neuropathic Pain
J Zhu, J Yang, J Xu - Pain Research and Management, 2021 - Wiley Online Library
Background. miRNA is an essential factor in neuropathic pain. However, the underlying
mechanism of miRNA in neuropathic pain remains unclear. Objective. To explore the …
mechanism of miRNA in neuropathic pain remains unclear. Objective. To explore the …
A novel microglia-targeting strategy based on nanoparticle-mediated delivery of miR-26a-5p for long-lasting analgesia in chronic pain
Y Lu, S Liu, P Wang, X Guo, Z Qin, H Hou… - Journal of …, 2024 - Springer
Accumulating evidence supports the notion that microglia play versatile roles in different
chronic pain conditions. However, therapeutic strategies of chronic pain by targeting …
chronic pain conditions. However, therapeutic strategies of chronic pain by targeting …
[HTML][HTML] Effect of intrathecal injection of miRNA-138 on neuropathic pain in rats undergoing partial sciatic nerve ligation and its underlying mechanism
Y Jin, L Xu, Y Xu - Annals of Palliative Medicine, 2021 - apm.amegroups.org
Background: microRNA-138 (miRNA-138) might have a promising therapeutic effect in the
Neuropathic pain (NP). We aim to investigate the effects of miRNA-138 on NP and explore …
Neuropathic pain (NP). We aim to investigate the effects of miRNA-138 on NP and explore …
[HTML][HTML] Nanoparticle–microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis
Q Luo, Y Feng, Y Xie, Y Shao, M Wu, X Deng… - … , Biology and Medicine, 2019 - Elsevier
Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the
application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral …
application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral …