[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Improving polygenic prediction in ancestrally diverse populations
Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …
existing genome-wide association studies (GWAS) have been conducted predominantly in …
[HTML][HTML] PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics
Polygenic risk scores (PRSs) have wide applications in human genetics research, but often
include tuning parameters which are difficult to optimize in practice due to limited access to …
include tuning parameters which are difficult to optimize in practice due to limited access to …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
[PDF][PDF] Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …
XPXP: improving polygenic prediction by cross-population and cross-phenotype analysis
Motivation As increasing sample sizes from genome-wide association studies (GWASs),
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …
[PDF][PDF] A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits
The development of polygenic risk scores (PRSs) has proved useful to stratify the general
European population into different risk groups. However, PRSs are less accurate in non …
European population into different risk groups. However, PRSs are less accurate in non …
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …
health disparities. We propose PolyPred, a method that improves cross-population …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
[HTML][HTML] Winner's curse correction and variable thresholding improve performance of polygenic risk modeling based on genome-wide association study summary-level …
Recent heritability analyses have indicated that genome-wide association studies (GWAS)
have the potential to improve genetic risk prediction for complex diseases based on …
have the potential to improve genetic risk prediction for complex diseases based on …