Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography–tandem mass spectrometry

Y Otoki, S Kato, F Kimura, K Furukawa… - … of Pharmaceutical and …, 2017 - Elsevier
Concentration of both choline plasmalogen (PC-Pls) and ethanolamine Pls (PE-Pls) in
human plasma/serum has been getting attention to, since certain patients including those …

[HTML][HTML] Rapid identification of plasmalogen molecular species using targeted multiplexed selected reaction monitoring mass spectrometry

AK Azad, H Kobayashi, AM Sheikh, H Osago… - Journal of Mass …, 2021 - Elsevier
Plasmalogens (Pls) levels are reported to be altered in several neurological and metabolic
diseases. Identification of sn-1 fatty alcohols and sn-2 fatty acids of different Pls species is …

MS/MS and LC-MS/MS analysis of choline/ethanolamine plasmalogens via promotion of alkali metal adduct formation

Y Otoki, K Nakagawa, S Kato, T Miyazawa - Journal of Chromatography B, 2015 - Elsevier
Tandem mass spectrometry (MS/MS) has been used for the analysis of plasmalogen (Pls), a
physiologically important class of vinyl ether-linked phospholipid. However, MS/MS …

Improvement and validation of 125I-high-performance liquid chromatography method for determination of total human serum choline and ethanolamine …

R Maeba, Y Yamazaki, T Nezu… - Annals of Clinical …, 2012 - journals.sagepub.com
Background Serum plasmalogens (Pls) have gained interest in several clinical symptoms
such as metabolic syndrome/atherosclerosis or Alzheimer's disease possibly because of …

[HTML][HTML] Time-dependent analysis of plasmalogens in the hippocampus of an Alzheimer's disease mouse model: A role of ethanolamine plasmalogen

AK Azad, AM Sheikh, MA Haque, H Osago, H Sakai… - Brain Sciences, 2021 - mdpi.com
Plasmalogens are alkenyl-acyl glycerophospholipids and decreased in post-mortem
Alzheimer's disease (AD) brains. The aim of this study is to investigate the time-dependent …

Biological functions of plasmalogens

MS Hossain, S Mawatari, T Fujino - Peroxisome biology: Experimental …, 2020 - Springer
Plasmalogens (Pls) are one kind of phospholipids enriched in the brain and other organs.
These lipids were thought to be involved in the membrane bilayer formation and anti-oxidant …

Plasmalogen in the brain: Effects on cognitive functions and behaviors attributable to its properties

J Udagawa, K Hino - Brain research bulletin, 2022 - Elsevier
Ether phospholipid compositions are altered in the plasma or brain of patients with brain
disorders, such as Alzheimer and Parkinson's disease, including those with psychiatric …

Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry

X Han, DM Holtzman… - Journal of …, 2001 - Wiley Online Library
To explore the hypothesis that alterations in ethanolamine plasmalogen may be directly
related to the severity of dementia in Alzheimer's disease (AD), we performed a systematic …

Therapeutic efficacy of plasmalogens for Alzheimer's disease, mild cognitive impairment, and Parkinson's disease in conjunction with a new hypothesis for the etiology …

T Fujino, MS Hossain, S Mawatari - Peroxisome biology: experimental …, 2020 - Springer
It has been reported in recent years that blood levels of plasmalogens (Pls) are decreased in
various diseases. None of those reports, however, conducted any clinical trials to examine …

From brain to food: Analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin–plasmalogens derivates in Alzheimer's disease human post …

MOW Grimm, S Grösgen, M Riemenschneider… - … of Chromatography A, 2011 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular senile plaques mainly consisting of Aβ, a 40–42 amino acid long peptide, and …