Muscle atrophy results from a variety of conditions such as disease states, neuromuscular
injuries, disuse, and aging. Absence of gravitational loading during spaceflight or long-term …

Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Muscle disuse is often observed after injury or during periods of illness, resulting in the loss
of muscle mass and strength, with sometimes debilitating consequences. Although …

In response to atrophic stimuli, physical alterations include decreases in fiber diameter and
contractile protein content. Despite the fact that these phenotypical alterations have been …

Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint
immobilization and bed rest, and is induced by a combination of unloading and inactivity …

Situations such as recovery from injury or illness require otherwise healthy humans to
undergo periods of disuse, which lead to considerable losses of skeletal muscle mass and …

Periods of immobilisation are often associated with pathologies and/or ageing. These
periods of muscle disuse induce muscle atrophy which could worsen the pathology or …

Skeletal muscle fibers have a unique capacity to adjust their metabolism and phenotype in
response to alternations in mechanical loading. Indeed, chronic mechanical loading leads to …

Situations such as the recovery from injury and illness can lead to enforced periods of
muscle disuse or unloading. Such circumstances lead to rapid skeletal muscle atrophy, loss …

Disuse atrophy is a common clinical problem. There is a need for therapeutic interventions
that do not involve exercise. A better understanding of the changes, particularly at the …