Novel therapeutic approaches for pulmonary fibrosis

A Datta, CJ Scotton… - British journal of …, 2011 - Wiley Online Library
Pulmonary fibrosis represents the end stage of a number of heterogeneous conditions and
is, to a greater or lesser degree, the hallmark of the interstitial lung diseases. It is …

Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies

B Selvarajah, M Platé, RC Chambers - Molecular Aspects of Medicine, 2023 - Elsevier
Fibrosis is the concluding pathological outcome and major cause of morbidity and mortality
in a number of common chronic inflammatory, immune-mediated and metabolic diseases …

Pathogenetic pathways and novel pharmacotherapeutic targets in idiopathic pulmonary fibrosis

KM Antoniou, A Pataka, D Bouros… - Pulmonary pharmacology …, 2007 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a poorly understood disease that usually leads to death
within 5 years of diagnosis. Despite our better understanding of IPF pathogenesis, the …

[HTML][HTML] Progress in understanding and treating idiopathic pulmonary fibrosis: Recent insights and emerging therapies

H Guo, J Sun, S Zhang, Y Nie, S Zhou… - Frontiers in …, 2023 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a long-lasting, continuously advancing, and irrevocable
interstitial lung disorder with an obscure origin and inadequately comprehended …

[HTML][HTML] Challenges for clinical drug development in pulmonary fibrosis

ES White, M Thomas, S Stowasser… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a pathologic process associated with scarring of the lung interstitium.
Interstitial lung diseases (ILDs) encompass a large and heterogenous group of disorders, a …

Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis

M Gharaee-Kermani, SH Phan - Current pharmaceutical design, 2005 - ingentaconnect.com
Pulmonary fibrosis is characterized by lung inflammation and abnormal tissue repair,
resulting in the replacement of normal functional tissue with an abnormal accumulation of …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

[HTML][HTML] Idiopathic pulmonary fibrosis: an update on pathogenesis

Q Mei, Z Liu, H Zuo, Z Yang, J Qu - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Update on therapeutic management of idiopathic pulmonary fibrosis

A Tzouvelekis, F Bonella… - Therapeutics and clinical …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive diffuse parenchymal lung
disease of unknown origin, with a mortality rate exceeding that of many cancers. The …

Idiopathic pulmonary fibrosis: new insights in its pathogenesis

A Pardo, M Selman - The international journal of biochemistry & cell biology, 2002 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a unique type of chronic fibrosing lung disease of
unknown etiology. The sequence of the pathogenic mechanisms is unknown, but the …