Emerging role of immune cells as drivers of pulmonary fibrosis

SE Mutsaers, T Miles, CM Prêle, GF Hoyne - Pharmacology & Therapeutics, 2023 - Elsevier
The pathogenesis of pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and
other forms of interstitial lung disease, involves a complex interplay of various factors …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Pulmonary fibrosis: cellular and molecular events

MS Razzaque, T Taguchi - Pathology international, 2003 - Wiley Online Library
Connective tissue remodeling of the interstitium is an important feature of chronic lung
diseases encompassing interstitial inflammatory changes and subsequent pulmonary …

Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction

DF Zoz, WE Lawson, TS Blackwell - The American journal of the medical …, 2011 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, interstitial
infiltrates in lung parenchyma and restriction on pulmonary function testing. IPF is the most …

Fibrosing interstitial lung diseases: knowns and unknowns

V Cottin, L Wollin, A Fischer… - European …, 2019 - Eur Respiratory Soc
Patients with certain types of fibrosing interstitial lung disease (ILD) are at risk of developing
a progressive phenotype characterised by self-sustaining fibrosis, decline in lung function …

Pulmonary fibrosis: a disease of alveolar collapse and collagen deposition

J Snijder, J Peraza, M Padilla… - Expert review of …, 2019 - Taylor & Francis
Introduction: Idiopathic pulmonary fibrosis (IPF) is a relentless form of fibrotic lung disease
with a median survival of approximately 3 years after diagnosis and a mortality rate that …

Pulmonary macrophages: a new therapeutic pathway in fibrosing lung disease?

AJ Byrne, TM Maher, CM Lloyd - Trends in molecular medicine, 2016 - cell.com
Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or
respiratory failure and has an average life expectancy of 3 years from diagnosis …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …

The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis

BD Bringardner, CP Baran, TD Eubank… - Antioxidants & redox …, 2008 - liebertpub.com
The role of inflammation in idiopathic pulmonary fibrosis (IPF) is controversial. If
inflammation were critical to the disease process, lung pathology would demonstrate an …

Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …