Human kidney tissue can now be generated via the directed differentiation of human
pluripotent stem cells. This advance is anticipated to facilitate the modeling of human kidney …

Kidney disease affects a significant portion of the global population, yet effective therapies
are lacking despite advancements in identifying genetic causes. This limitation can be …

A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …

Genetic or hereditary kidney disease stands as a pivotal cause of chronic kidney disease
(CKD). The proliferation and widespread utilization of DNA testing in clinical settings have …

The coronavirus disease-19 (COVID-19) pandemic underscores the threat posed by newly
emerging viruses. Understanding the biology of novel viruses rests in large part on in vitro …

Background: Kidney disease causes major suffering and premature mortality worldwide.
With no cure for kidney failure currently available, and with limited options for treatment …

SARS-CoV-2, a newly emerged virus described for the first time in late 2019, affects multiple
organs in humans, including the pancreas. Here, we present the bilateral link between the …

COVID-19 is a systemic disease involving multiple organs. We previously established a
platform to derive organoids and cells from human pluripotent stem cells to model SARS …

Abstract On February 11, 2020, the World Health Organization officially announced the
coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome …

Summary Paragraph The SARS-CoV-2 virus has caused already over 3.5 million COVID-19
cases and 250,000 deaths globally. There is an urgent need to create novel models to study …