Fifty years have passed since the discovery of the first selenoprotein by Rotruck and
colleagues. In that time, the essential nature of selenium has come to light including the …

Selenoproteins are a distinct class of proteins that are characterized by the co-translational
incorporation of selenium (Se) in the form of the 21st amino acid selenocysteine …

Expression of selenoproteins is widespread in neurons of the central nervous system. There
is continuous evidence presented over decades that low levels of selenium or …

After the discovery of selenium (Se) as an essential trace element, direct evidence that Se
plays a role in brain function remained relatively scarce for many years. This was probably …

Selenium (Se) is an essential trace mineral mediating its biological function primarily
through selenoproteins. Accumulated lines of evidence indicate important roles of …

Eighteen years ago, unexpected epileptic seizures in Selenop-knockout mice pointed to a
potentially novel, possibly underestimated, and previously difficult to study role of selenium …

Multiple biological functions of selenium manifest themselves mainly via 25 selenoproteins
that have selenocysteine at their active centre. Selenium is vital for the brain and seems to …

It is unsurprising that our understanding of the role of selenium in neurological function is
somewhat immature, considering its relatively recent discovery as an essential element to …

The essential trace element selenium, as selenocysteine, is incorporated into antioxidant
selenoproteins such as glutathione peroxidases (GPx), thioredoxin reductases (TrxR) and …

Over the past three decades, selenium has been intensively investigated as an antioxidant
trace element. It is widely distributed throughout the body, but is particularly well maintained …