Early differences in cytokine production by severity of coronavirus disease 2019

LH Tjan, K Furukawa, T Nagano, T Kiriu… - The Journal of …, 2021 - academic.oup.com
Most patients with coronavirus disease 2019 (COVID-19) experience asymptomatic disease
or mild symptoms, but some have critical symptoms requiring intensive care. It is important to …

Profiling serum cytokines in COVID-19 patients reveals IL-6 and IL-10 are disease severity predictors

H Han, Q Ma, C Li, R Liu, L Zhao, W Wang… - Emerging microbes & …, 2020 - Taylor & Francis
Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly
spread across many other countries. While the majority of patients were considered mild …

[PDF][PDF] Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury

Y Liu, C Zhang, F Huang, Y Yang, F Wang… - National Science …, 2020 - academic.oup.com
A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel
coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical …

Cytokines and their relationship with the severity and prognosis of coronavirus disease 2019 (COVID-19): a retrospective cohort study

QQ Liu, A Cheng, Y Wang, H Li, L Hu, X Zhao… - BMJ open, 2020 - bmjopen.bmj.com
Objective To delineate the characteristics and clinical significance of plasma inflammatory
cytokines altered in COVID-19. Design Retrospective, single-centre cohort study. Setting …

[HTML][HTML] Elevated interleukin‐6 is associated with severity of COVID‐19: a meta‐analysis

J Zhu, J Pang, P Ji, Z Zhong, H Li, B Li… - Journal of medical …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID‐19) has spread rapidly around the world since its
emergence in humans last December. Previous studies suggested that numerous markers …

Interleukin‐6 in COVID‐19: a systematic review and meta‐analysis

EA Coomes, H Haghbayan - Reviews in medical virology, 2020 - Wiley Online Library
Coronaviruses may activate dysregulated host immune responses. As exploratory studies
have suggested that interleukin‐6 (IL‐6) levels are elevated in cases of complicated Covid …

[HTML][HTML] Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity

CK Kang, GC Han, M Kim, G Kim, HM Shin… - International Journal of …, 2020 - Elsevier
Objectives We hypothesized that immune response may contribute to progression of
coronavirus disease-19 (COVID-19) at the second week of illness. Therefore, we compared …

[HTML][HTML] High levels of circulating IL-8 and soluble IL-2R are associated with prolonged illness in patients with severe COVID-19

A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang… - Frontiers in …, 2021 - frontiersin.org
Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and …

[HTML][HTML] The anti-inflammatory cytokine response characterized by elevated interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro …

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
Objectives Severe coronavirus disease 2019 (COVID-19) is associated with a dysregulated
immune state. While research has focused on the hyperinflammation, little research has …

[HTML][HTML] Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

JG Wilson, LJ Simpson, AM Ferreira, A Rustagi… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …