Epigenetic mechanisms might play a role in the pathophysiology of hypertension, a major
risk factor for cardiovascular disease and renal failure. We aimed to systematically review …

Hypertension is a multifactorial disease influenced by an interaction of environmental and
genetic factors. The exact molecular mechanism of hypertension remains unknown …

Systemic hypertension, which eventually results in heart failure, renal failure or stroke, is a
common chronic human disorder that particularly affects elders. Although many signaling …

Genetic studies of DNA have been unable to explain a significant portion of the variance of
the estimated heritability of blood pressure (BP). Epigenetic mechanisms, particularly DNA …

Physical, chemical, and social environments adversely affect the molecular process and
results in cell signal transduction and the subsequent transcription factor dysregulation …

DNA methylation is the covalent modification of DNA that affects its function, without altering
DNA sequences. Three important roles of DNA methylation include intrauterine …

Epigenetic phenomena include DNA methylation, post-translational histone modifications,
and noncoding RNAs, as major marks. Although similar to genetic features of DNA for their …

We conducted an epigenome-wide association study meta-analysis on blood pressure (BP)
in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA …

The epigenome likely interacts with traditional and genetic risk factors to influence blood
pressure. We evaluated whether 13 previously reported DNA methylation sites (CpGs) are …

BACKGROUND: Despite advances in understanding hypertension's genetic structure, how
noncoding genetic variants influence it remains unclear. Studying their interaction with DNA …