In the conventional model of transcriptional activation, transcription factors bind to response
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …

Heterozygous mutations in the histone lysine acetyltransferase gene KAT6B
(MYST4/MORF/QKF) underlie neurodevelopmental disorders, but the mechanistic roles of …

Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Epigenetic integrity is critical for many eukaryotic cellular processes. An important question
is how different epigenetic regulators control development and influence disease. Lysine …

Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …

The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …

Neural stem cells (NSCs) proliferation and differentiation rely on proper expression and
posttranslational modification of transcription factors involved in the determination of cell …

Chromatin remodeling is fundamental for the dynamical changes in transcriptional programs
that occur during development and stem cell differentiation. The histone acetyltransferase …

Cell fate transitions in mammalian stem cell systems have often been associated with
transcriptional heterogeneity; however, existing data have failed to establish a functional or …

The lysine acetyltransferase 6 (KAT6) histone acetyltransferase (HAT) complexes are highly
conserved from yeast to higher organisms. They acetylate histone H3 and other nonhistone …