Bioinformatic Analysis Reveals Central Role for Tumor‐Infiltrating Immune Cells in Uveal Melanoma Progression

M Lachota, A Lennikov, KJ Malmberg… - Journal of …, 2021 - Wiley Online Library
Tumor‐infiltrating immune cells are capable of effective cancer surveillance, and their
abundance is linked to better prognosis in numerous tumor types. However, in uveal …

[HTML][HTML] Identification of immune cell infiltration landscape and their prognostic significance in uveal melanoma

H Zhao, Y Chen, P Shen, L Gong - Frontiers in Cell and …, 2021 - frontiersin.org
Uveal melanoma (UVM) is the most common primary intraocular cancer in adults. Increasing
evidence has demonstrated that immune cell infiltration (ICI) is crucial in predicting patient …

[HTML][HTML] Landscape of infiltrated immune cell characterization in uveal melanoma to improve immune checkpoint blockade therapy

X Lv, M Ding, Y Liu - Frontiers in Immunology, 2022 - frontiersin.org
Background Numerous studies indicated that tumor-infiltrated immune cells (TIC) in the
microenvironment are substantially linked to immunotherapy response and cancer …

[HTML][HTML] Construction of a promising tumor-infiltrating CD8+ T cells gene signature to improve prediction of the prognosis and immune response of uveal melanoma

Y Sun, J Wu, Y Yuan, Y Lu, M Luo, L Lin… - Frontiers in cell and …, 2021 - frontiersin.org
Background CD8+ T cells work as a key effector of adaptive immunity and are closely
associated with immune response for killing tumor cells. It is crucial to understand the role of …

[HTML][HTML] Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis

S Chen, Z Tang, Q Wan, W Huang, X Li, X Huang… - Cancer Cell …, 2024 - Springer
Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

[HTML][HTML] Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

[HTML][HTML] Additive role of immune system infiltration and angiogenesis in uveal melanoma progression

S García-Mulero, MH Alonso, LP Del Carpio… - International journal of …, 2021 - mdpi.com
Uveal melanoma (UM) is a malignant tumor that arises in the melanocytes of the uveal tract.
It is the most frequent eye cancer, and despite new therapeutic approaches, prognosis is still …

Identification and validation of an immune-relevant risk signature predicting survival outcome and immune infiltration in uveal melanoma

X Sun, Q Li, G Xu - International Ophthalmology, 2023 - Springer
Purpose The current study aimed to reveal a novel immune-related signature to evaluate
immune infiltration status and the survival outcome for patients with uveal melanoma (UM) …

[HTML][HTML] Identification of precise therapeutic targets and characteristic prognostic genes based on immune gene characteristics in uveal melanoma

Z Zhang, J Su, L Li, W Du - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
The tumor microenvironment is an important factor for the immunotherapy of tumor patients.
The sequenced transcriptome data can be used to describe the tumor microenvironment …

[HTML][HTML] Immunogenic profiling of metastatic uveal melanoma discerns a potential signature related to prognosis

J Wang, M Liu, J Sun, Z Zhang - Journal of Cancer Research and Clinical …, 2024 - Springer
Background Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The
present study aimed to identify the key genes associated with UM metastasis and …