In patients with diabetes mellitus, poor metabolic control has a long-lasting impact on kidney
disease development. Epigenetic changes, including cytosine methylation, have been …

Background We investigated a cross-sectional epigenome-wide association study of
patients with early and late diabetes-associated chronic kidney disease (CKD) to identify …

Poor metabolic control and host genetic predisposition are critical for diabetic kidney
disease (DKD) development. The epigenome integrates information from sequence …

Chronic kidney disease (CKD) is an emerging public health priority associated with high
mortality rates and demanding treatment regimens, including life-style changes, medications …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Variation in DNA methylation (DNAmet) in white blood cells and other cells/tissues has been
implicated in the etiology of progressive diabetic kidney disease (DKD). However, the …

Epigenetic changes might provide the biological explanation for the long-lasting impact of
metabolic alterations of diabetic kidney disease development. Here we examined cytosine …

Background Diabetic nephropathy is a serious complication of diabetes mellitus and is
associated with considerable morbidity and high mortality. There is increasing evidence to …

A subset of individuals with type 1 diabetes will develop diabetic kidney disease (DKD).
DKD is heritable and large-scale genome-wide association studies have begun to identify …

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …