Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice

C Wang, X Zheng, W Gai, G Wong, H Wang, H Jin… - Antiviral research, 2017 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has continued spreading since
its emergence in 2012 with a mortality rate of 35.6%, and is a potential pandemic threat …

A novel bacterium-like particle vaccine displaying the MERS-CoV receptor-binding domain induces specific mucosal and systemic immune responses in mice

E Li, H Chi, P Huang, F Yan, Y Zhang, C Liu, Z Wang… - Viruses, 2019 - mdpi.com
Middle East respiratory syndrome coronavirus (MERS-CoV), a new coronavirus that has
been causing severe and fatal acute respiratory illnesses in humans since its outbreak in …

A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization

R Liu, J Wang, Y Shao, X Wang, H Zhang, L Shuai… - Antiviral research, 2018 - Elsevier
Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening
zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to …

[HTML][HTML] MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques

C Wang, X Zheng, W Gai, Y Zhao, H Wang, H Wang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory
disease in humans with a case fatality rate of over 39%, and poses a considerable threat to …

Characterization of the immune response of MERS-CoV vaccine candidates derived from two different vectors in mice

E Li, F Yan, P Huang, H Chi, S Xu, G Li, C Liu, N Feng… - Viruses, 2020 - mdpi.com
Middle East respiratory syndrome (MERS) is an acute, high-mortality-rate, severe infectious
disease caused by an emerging MERS coronavirus (MERS-CoV) that causes severe …

Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein

SS Al-Amri, AT Abbas, LA Siddiq, A Alghamdi… - Scientific reports, 2017 - nature.com
MERS-coronavirus is a novel zoonotic pathogen which spread rapidly to> 25 countries since
2012. Its apparent endemicity and the wide spread of its reservoir host (dromedary camels) …

Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection

Y Wang, W Tai, J Yang, G Zhao, S Sun… - Human vaccines & …, 2017 - Taylor & Francis
Middle East respiratory syndrome (MERS) continues to raise worldwide concerns due to its
pandemic potential. Increased MERS cases and no licensed MERS vaccines highlight the …

Particulate multivalent presentation of the receptor binding domain induces protective immune responses against MERS-CoV

NMA Okba, I Widjaja, B van Dieren… - Emerging microbes & …, 2020 - Taylor & Francis
Middle East respiratory syndrome coronavirus (MERS-CoV) is a WHO priority pathogen for
which vaccines are urgently needed. Using an immune-focusing approach, we created self …

Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus

Y Deng, J Lan, L Bao, B Huang, F Ye… - Emerging Microbes & …, 2018 - Taylor & Francis
The persistent public health threat of infection with Middle East respiratory syndrome
coronavirus (MERS-CoV) highlights the need for an effective and safe MERS-CoV vaccine …

Anti-S1 MERS-COV IgY specific antibodies decreases lung inflammation and viral antigen positive cells in the human transgenic mouse model

AT Abbas, SA El-Kafrawy, SS Sohrab, AA Tabll… - Vaccines, 2020 - mdpi.com
The Middle East respiratory syndrome coronavirus (MERS-CoV) was identified in 2012 and
causes severe and often fatal acute respiratory illness in humans. No approved prophylactic …