Background The high comorbidity rate between bipolar disorder (BP) and anxiety disorder
(AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan …

Background Generalized anxiety disorder (GAD) is a common psychiatric disorder
characterized by long-term worry, tension, nervousness, fidgeting, and symptoms of …

Numerous studies have reported on the roles of genetic factors in the development of
depression in adolescents and young adults. However, there are few systematic reviews that …

Brain-derived neurotrophic factor (BDNF) plays important roles in cell survival, neural
plasticity, learning, and stress regulation. However, whether the recently found human BDNF …

BackgroundThe role of the brain-derived neurotrophic factor (BDNF) in the pathogenesis of
affective disorders such as depression has been controversial. Mounting evidence comes …

Objective: Clinical and biological correlates of resilience in major depressive disorder are
scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene …

Mounting evidence shows that the brain derived neurotrophic factor (BDNF) plays a crucial
role in depression and anxiety. The discovery of a functional variant of the BDNF gene–the …

There have been controversial results regarding the association between brain-derived
neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm …

BackgroundAdverse childhood experiences have been described as one of the major
environmental risk factors for depressive disorder. Similarly, the deleterious impact of early …

Objective Genetic imaging is used to investigate the mechanism by which genetic variants
influence brain structure. In a previous study, a structural change of the dorsolateral …