H3. 3K122A results in a neomorphic phenotype in mouse embryonic stem cells

BJ Patty, C Jordan, SM Lardo, K Troy… - Epigenetics & Chromatin, 2024 - Springer
Canonical histone H3 and histone variant H3. 3 are posttranslationally modified with the
genomic distribution of these marks denoting different features and these modifications may …

Histone H3. 3 regulates mitotic progression in mouse embryonic fibroblasts

A Ors, C Papin, B Favier, Y Roulland… - … and Cell Biology, 2017 - cdnsciencepub.com
H3. 3 is a histone variant that marks transcription start sites as well as telomeres and
heterochromatic sites on the genome. The presence of H3. 3 is thought to positively …

Histone variant H3. 3 maintains a decondensed chromatin state essential for mouse preimplantation development

CJ Lin, M Conti, M Ramalho-Santos - Development, 2013 - journals.biologists.com
Histone variants can replace canonical histones in the nucleosome and modify chromatin
structure and gene expression. The histone variant H3. 3 preferentially associates with …

The many faces of H3. 3 in regulating chromatin in embryonic stem cells and beyond

LRZ Cohen, E Meshorer - Trends in Cell Biology, 2024 - cell.com
H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

High-resolution mapping of h1 linker histone variants in embryonic stem cells

K Cao, N Lailler, Y Zhang, A Kumar, K Uppal, Z Liu… - PLoS …, 2013 - journals.plos.org
H1 linker histones facilitate higher-order chromatin folding and are essential for mammalian
development. To achieve high-resolution mapping of H1 variants H1d and H1c in embryonic …

Phosphorylation of histone H3. 3 at serine 31 promotes p300 activity and enhancer acetylation

S Martire, AA Gogate, A Whitmill, A Tafessu, J Nguyen… - Nature …, 2019 - nature.com
The histone variant H3. 3 is enriched at enhancers and active genes, as well as repeat
regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs) …

Developmentally programmed histone H3 expression regulates cellular plasticity at the parental-to-early embryo transition

RJ Gleason, Y Guo, CS Semancik, C Ow… - Science …, 2023 - science.org
During metazoan development, the marked change in developmental potential from the
parental germline to the embryo raises an important question regarding how the next life …

Histone H1 variants are differentially expressed and incorporated into chromatin during differentiation and reprogramming to pluripotency

JM Terme, B Sesé, L Millán-Ariño, R Mayor… - Journal of Biological …, 2011 - ASBMB
There are seven linker histone variants in human somatic cells (H1. 0 to H1. 5 and H1X),
and their prevalence varies as a function of cell type and differentiation stage, suggesting …

Histone H3. 3 maintains genome integrity during mammalian development

CW Jang, Y Shibata, J Starmer, D Yee… - Genes & …, 2015 - genesdev.cshlp.org
Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

Role of H1 linker histones in mammalian development and stem cell differentiation

C Pan, Y Fan - Biochimica et Biophysica Acta (BBA)-Gene Regulatory …, 2016 - Elsevier
H1 linker histones are key chromatin architectural proteins facilitating the formation of higher
order chromatin structures. The H1 family constitutes the most heterogeneous group of …