Ribosome biogenesis in the nucleolus is an important process that consumes 80% of a cell's
intracellular energy supply. Disruption of this process results in nucleolar stress, triggering …

Cell growth demands new protein synthesis, which requires nucleolar ribosomal functions.
Ribosome biogenesis consumes a large proportion of the cell's resources and energy, and …

The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

Nucleolar stress reflects a misfunction of the nucleolus caused by a failure in ribosome
biogenesis and defective nucleolar architecture. Various causes have been reported, most …

The nucleolus is a prominent subnuclear compartment, where ribosome biosynthesis takes
place. Recently, the nucleolus has gained attention for its novel role in the regulation of …

Ribosome biogenesis is a vital and highly energy-consuming cellular function occurring
primarily in the nucleolus. Cancer cells have an elevated demand for ribosomes to sustain …

Cell proliferation and cell growth are two tightly linked processes, as the proliferation
program cannot be executed without proper accumulation of cell mass, otherwise …

The nucleolus is the site of ribosome biogenesis, a complex process that requires the
coordinate activity of all three RNA polymerases and hundreds of non-ribosomal factors that …