Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing
and increased membrane permeability. Caspase-1 and caspase-11 have been considered …

Pyroptosis is a proinflammatory mode of lytic cell death mediated by accumulation of plasma
membrane (PM) macropores composed of gasdermin‐family (GSDM) proteins. It facilitates …

Sepsis is defined as a life‐threatening disease involving multiple organ dysfunction caused
by dysregulated host responses to infection. To date, sepsis remains a dominant cause of …

Inflammasome is an intracellular signaling complex of the innate immune system. Activation
of inflammasomes promotes the secretion of interleukin 1β (IL-1β) and IL-18 and triggers …

Gasdermin D (GSDMD) is a recently identified pore-forming protein that is crucial for the
execution of pyroptosis, a highly inflammatory form of cell death. GSDMD contains an N …

Pyroptosis is an active and ordered form of programmed cell death. The signaling pathways
of pyroptosis are mainly divided into canonical pathways mediated by caspase-1 and …

Pyroptosis is a programmed necrotic cell death mediated by pore-forming Gasdermin
(GSDM) proteins. After being unleashed from the C-terminal auto-inhibitory domains by …

Chemotherapy drugs can induce cancer cell death via a series of regulated cell death
(RCD) pathways including apoptosis and regulated necrosis (Vanden Berghe et al., 2014) …

Excessive inflammation and tissue damage during severe influenza A virus (IAV) infection
can lead to the development of fatal pulmonary disease. Pyroptosis is a lytic and pro …

Pyroptosis is a necrotic form of cell death that was initially found to be induced upon
activation of inflammatory caspases by inflammasome complexes. Mechanistically …