The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Cells undergo an inflammatory programmed lytic cell death called 'pyroptosis'(with the
Greek roots 'fiery'), often featuring morphological hallmarks such as large ballooning …

Programmed cell death is a key mechanism involved in several biological processes
ranging from development and homeostasis to immunity, where it promotes the removal of …

Pyroptosis is an active cell death process mediated by gasdermin family proteins including
Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D …

Abstract Gasdermin-E (GSDME), the executioner of pyroptosis when cleaved by caspase 3,
plays a crucial role in tumor defense and the response to chemotherapy drugs in cells. So …

Pyroptosis is a proinflammatory form of cell death, mediated by membrane pore-forming
proteins called gasdermins. Gasdermin pores allow the release of the pro-inflammatory …

Pyroptosis is a form of programmed cell death, which is executed by gasdermin family
proteins. Under the stimulation of pathogen-and/or damage-associated molecular patterns …

Background Pyroptosis is an inflammatory form of cell death that has been implicated in
various infectious and non-infectious diseases. Gasdermin family proteins are the key …

Pyroptosis, a newly characterized type of inflammatory programmed cell death (PCD), is
usually triggered by multiple inflammasomes which can recognize different danger or …

Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis,
necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases …