Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis,
necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases …

The innate immune system senses and responds to pathogens and endogenous damage
through supramolecular protein complexes known as inflammasomes. Cytosolic …

Journal Club Journal Club Journal Club Page 1 www.nature.com/nri 0123456789();: ReseaRch
highlights 620 | oCToBeR 2021 | voLuMe 21 Pathogeninduced inflammation manifests as an …

Pyroptosis is a process of programmed cell death mediated by gasdermin (GSDM) found in
recent years. In the process of pyroptosis, caspase-1 or caspase-11/4/5 is activated, which …

Pyroptosis is a form of pro-inflammatory, necrotic cell death mediated by proteins of the
gasdermin family. Various heart diseases, including myocardial ischemia/reperfusion injury …

Crohn's disease (CD) is a kind of refractory intestinal inflammatory diseases. Pyroptosis was
recently identified as a gasdermin-mediated proinflammatory cell death. However, it is …

Gasdermins are membrane pore–forming proteins that cause pyroptosis, an inflammatory
cell death in which cells burst and release cytokines, chemokines, and other host alarm …

Cytosolic pattern recognition receptors trigger pyroptosis by detection of danger-or pathogen-
associated molecular patterns. These receptors initiate the assembly of inflammasomes …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that
involve the formation of pores on cells, recognition of danger signals, and release of pro …