The engineering of synthetic gene networks has mostly relied on the assembly of few
characterized regulatory elements using rational design principles. It is of outmost …

Background Recent years has witnessed an increasing number of studies on constructing
simple synthetic genetic circuits that exhibit desired properties such as oscillatory behavior …

Synthetic regulatory networks with prescribed functions are engineered by assembling a
reduced set of functional elements. We could also assemble them computationally if the …

Synthetic gene circuits are designed to program new biological behaviour, dynamics and
logic control. For all but the simplest synthetic phenotypes, this requires a structured …

Recent studies have provided insights into the modular structure of genetic regulatory
networks and emphasized the interest of quantitative functional descriptions. Here, to …

Highlights•We review recent advances in the forward design of genetic circuits.•Advanced
circuit design concepts pave the way for more complex synthetic cellular regulation.•Part …

Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first
genetic circuits─ the repressilator and the toggle switch─ were designed and implemented …

Synthetic biology is a rapidly expanding discipline at the interface between engineering and
biology. Much research in this area has focused on gene regulatory networks that function …

In the field of synthetic biology, recent genetic engineering efforts have enabled the
construction of novel genetic circuits with diverse functionalities and unique activation …

Considerable progress has been made in identifying and characterizing the component
parts of genetic oscillators, which play central roles in all organisms. Nonlinear interaction …