The genetic architecture of testosterone is highly distinct between sexes. Moreover, obesity
is associated with higher testosterone in females but lower testosterone in males. Here, we …

Objective Type 2 diabetes mellitus (T2DM) is an endocrine-related disease with an
increasing incidence worldwide. Male sexual dysfunction is common in diabetic patients …

Background Testosterone levels are linked with diverse characteristics of human health, yet,
whether these associations reflect correlation or causation remains debated. Here, we …

Objective Epidemiological and clinical studies have highlighted important roles for sex
hormones in the regulation of fat distribution and systemic metabolism. We investigated the …

Testosterone concentrations in men are associated with cardiovascular morbidity,
osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of …

Background: Testosterone levels are differentially linked with diabetes risk in men and
women: lower testosterone levels in men and higher testosterone levels in women are …

Background Observationally lower testosterone is associated with an unhealthier
cardiovascular (CVD) risk profile, but this association is open to confounding and reverse …

Testosterone supplementation is commonly used for its effects on sexual function, bone
health and body composition, yet its effects on disease outcomes are unknown. To better …

Background Testosterone supplementation has been linked to increased cardiovascular
disease risk in some observational studies. The causal role of testosterone can be …

Sex differences have been shown in laboratory biomarkers; however, the extent to which
this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters …