Genetic associations of birthweight, childhood, and adult bmi on testosterone levels: a mendelian randomization

Z Jian, C Yuan, L Ma, X Jin - The Journal of Clinical …, 2022 - academic.oup.com
Context Birthweight, childhood, and adult BMI have been indicated associated with the
testosterone levels, but the current studies are plagued by significant heterogeneity, and a …

Dyslipidaemia is associated with testosterone, oestradiol and androgen receptor CAG repeat polymorphism in men with type 2 diabetes

RD Stanworth, D Kapoor, KS Channer… - Clinical …, 2011 - Wiley Online Library
Objective There is a high prevalence of low testosterone and dyslipidaemia in men with type
2 diabetes. The androgen receptor CAG repeat polymorphism (AR CAG) affects receptor …

Serum testosterone, sex hormone‐binding globulin and sex‐specific risk of incident type 2 diabetes in a retrospective primary care cohort

MW O'Reilly, M Glisic, B Kumarendran… - Clinical …, 2019 - Wiley Online Library
Objective Previous studies suggest that androgens have a sexually dimorphic impact on
metabolic dysfunction. However, the sex‐specific link between circulating androgens and …

Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis

Q Yao, B Wang, X An, J Zhang… - Endocrine …, 2018 - ec.bioscientifica.com
Background Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex
steroid status. Some studies also investigated the association of testosterone level with …

Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans

A Chakrabarty, S Chakraborty… - Proceedings of the …, 2024 - National Acad Sciences
Sex difference (SD) is ubiquitous in humans despite shared genetic architecture (SGA)
between the sexes. A univariate approach, ie, studying SD in single traits by estimating …

Sex-specific causal relations between steroid hormones and obesity—a Mendelian randomization study

J Pott, K Horn, R Zeidler, H Kirsten, P Ahnert… - Metabolites, 2021 - mdpi.com
Steroid hormones act as important regulators of physiological processes including gene
expression. They provide possible mechanistic explanations of observed sex-dimorphisms …

Cross-ancestry genome-wide association studies of sex hormone concentrations in pre-and postmenopausal women

CB Haas, L Hsu, JW Lampe, KJ Wernli… - …, 2022 - academic.oup.com
Objective Concentrations of circulating sex hormones have been associated with a variety of
diseases in women and are strongly influenced by menopausal status. We investigated the …

Genetically predicted androgenic profiles and adverse cardiac markers: a sex‐specific Mendelian randomization study

JY Chen, M Ardissino, RK Reddy, AM Mason… - ESC Heart …, 2023 - Wiley Online Library
Aims Observational evidence suggests associations between sex hormone levels and heart
failure (HF). We used sex‐specific genetic variants associated with androgenic sex hormone …

Low testosterone concentrations in men contribute to the gender gap in cardiovascular morbidity and mortality

R Haring, U John, H Völzke, M Nauck, M Dörr, SB Felix… - Gender medicine, 2012 - Elsevier
BACKGROUND: Across the industrialized world, men experience an earlier onset of
cardiovascular disease (CVD) and a life expectancy 5 to 10 years shorter than women. Low …

Body composition and testosterone in men: a Mendelian randomization study

Y Ikehata, T Hachiya, T Kobayashi, H Ide… - Frontiers in …, 2023 - frontiersin.org
Background Testosterone is an essential sex hormone that plays a vital role in the overall
health and development of males. It is well known that obesity decreases testosterone …