We recently devised continuous “sex-scores” that sum up multiple quantitative traits,
weighted by their respective sex-difference effect sizes, as an approach to estimating …

Context: Epidemiologic studies suggest that endogenous testosterone (T) levels in males
may be implicated in cardiovascular disease (CVD), however further clarification is needed …

Testosterone deficiency (TD) has become a frequently diagnosed condition in our current
society with an obesity epidemic. Men diagnosed with TD often have co-morbidities …

Introduction We aimed to systematically investigate the association between testosterone
level and cardiovascular risk in male patients with type 2 diabetes mellitus (T2DM) by …

Background Type 2 Diabetes Mellitus (T2DM) is characterised by hyperglycemia due to the
incidence of insulin resistance. Testosterone supplementation has been shown to have a …

Twin studies suggest a heritable component to circulating sex steroid hormones and sex
hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort …

Aims To assess the implications of low testosterone on cardiovascular risk factors, metabolic
syndrome (MES) and clinical outcomes in Chinese men with Type 2 Diabetes (T2D) …

Objective Reduced testosterone, a recognized comorbidity of reduced insulin sensitivity (IS)
and type 2 diabetes (T2D), has also been reported in adult males with type 1 diabetes (T1D) …

Generally, high testosterone levels within the physiological range are associated with a
more favourable cardiometabolic profile. Although the FDA has approved testosterone for …

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and
biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has …