We screened for viral DNA in cerebrospinal fluid samples using next-generation sequencing
(NGS) technology to diagnose CNS viral infections. We collected CSF samples from four …

Background Encephalitis is a severe neurological syndrome usually caused by viruses.
Despite significant progress in diagnostic techniques, the causative agent remains …

Identification of pathogens causing viral encephalitis remains challenging, and in over 50%
of cases the etiologic factor remains undetermined. Next-generation sequencing (NGS) …

Background Viral aetiologies are the most common cause of central nervous system (CNS)
infections. Approximately one-half of CNS infections remain of undetermined origin. High …

Hundreds of viruses cause central nervous system (CNS) disease, including
meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal …

Acute encephalitis/encephalopathy is a severe neurological syndrome that is occasionally
associated with viral infection. Comprehensive virus detection assays are desirable because …

Background: Epidemiological studies have indicated that the majority of cases of aseptic
meningitis result from viral infections. However, specific viral pathogens for aseptic …

ABSTRACT A multiplex PCR assay that detects the four commonest causes of viral
meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV …

The use of nucleic acid (NA) amplification techniques has transformed the diagnosis of viral
infections of the central nervous system (CNS). Because of their enhanced sensitivity, these …

Efficient and sensitive diagnostic methods are needed in the management of virus infections
in the central nervous system. There is a demand for an evaluation of the sensitivity of PCR …