Abstract Introduction Interleukin-6 (IL-6) is an important mediator of inflammation. In addition
to cells involved in inflammation, sensory nociceptive neurons express the IL-6 signal …

Proinflammatory cytokines are major mediators in the pathogenesis of diseases of joints
such as rheumatoid arthritis and osteoarthritis. This review emphasizes that proinflammatory …

Objective Significant joint pain is usually widespread beyond the affected joint, which results
from the sensitization of nociceptive neurons in the central nervous system (central …

Objective In arthritis, macrophages invade the affected joint. Experimental arthritis models
have shown that macrophages also invade the dorsal root ganglia (DRGs) of the inflamed …

Objective In spite of successful treatment of immune‐mediated arthritis, many patients still
experience pain. We undertook this study to investigate whether antigen‐induced arthritis …

Objective To evaluate the contribution of sensory neurons in ankle joints and adjacent tissue
to the development of pain in collagen‐induced arthritis (CIA), and to determine the …

The proinflammatory cytokines tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6) not
only promote and maintain inflammation, they also contribute to the generation and …

Innervation of the joint with thinly myelinated and unmyelinated sensory nerve fibres is
crucial for the occurrence of joint pain. During inflammation in the joint, sensory fibres show …

Abstract Objective Interleukin‐17 (IL‐17) is considered a proinflammatory cytokine, but
whether neuronal IL‐17 receptors contribute to the generation of arthritic pain is unknown …

Introduction Pain in arthritis may be experienced in regions outside the affected joint, and
hyperalgesia may even be widespread. The spread of pain is usually attributed to …