The human beta-coronavirus strain, OC43, provides a useful model for testing the antiviral
activity of various agents. We compared the activity of several antiviral drugs against OC43 …

Remdesivir, a prodrug targeting RNA-dependent-RNA-polymerase, and cyclosporine, a
calcineurin inhibitor, individually exerted inhibitory activity against human coronavirus OC43 …

Abstract Human coronavirus NL63 (HCoV-NL63) mainly affects young children and
immunocompromised patients, causing morbidity and mortality in a subset of patients. Since …

Abstract Human coronavirus OC43 (HCoV‐OC43) often causes common cold and is able to
neuroinvasive, but it can also induce lower respiratory tract infections (LRTI) especially in …

The recent COVID-19 pandemic has highlighted the urgency to develop effective antiviral
therapies against the disease. Murine hepatitis virus (MHV) is a coronavirus that infects mice …

The identification of a novel β coronavirus, nCoV, as the causative agent of severe
respiratory illness in humans originating in Saudi Arabia, Qatar and Jordan has raised …

Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for
the treatment of COVID-19. The prodrug is metabolized to its active triphosphate form and …

IFNβ, a member of the type I interferon (IFN-I) family, is currently approved in the form of a
recombinant protein in the European Union and the United States for the treatment of …

Ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lacks the intrinsic
ability to bind to the mouse ACE2 receptor, and therefore establishment of SARS-CoV-2 …

In addition to antibacterial effects, macrolide antibiotics exhibit other extensive
pharmacological effects, such as anti-inflammatory and antiviral activities. Erythromycin …