The use of cognitive enhancers in animal models of fear extinction

GB Kaplan, KA Moore - Pharmacology Biochemistry and Behavior, 2011 - Elsevier
In anxiety disorders, such as posttraumatic stress disorders and phobias, classical
conditioning pairs natural (unconditioned) fear-eliciting stimuli with contextual or discrete …

Can fear extinction be enhanced? A review of pharmacological and behavioral findings

PJ Fitzgerald, JR Seemann, S Maren - Brain research bulletin, 2014 - Elsevier
There is considerable interest, from both a basic and clinical standpoint, in gaining a greater
understanding of how pharmaceutical or behavioral manipulations alter fear extinction in …

Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy

M Davis, KM Myers, J Chhatwal, KJ Ressler - NeuroRx, 2006 - Springer
A great deal is now known about the mechanisms of conditioned fear acquisition and
expression. More recently, the mechanisms of inhibition of conditioned fear have become …

Fear extinction in rodents: basic insight to clinical promise

M Barad - Current opinion in neurobiology, 2005 - Elsevier
Fear extinction, the reduction of fear by repeated exposure to the object of fear, is a crucial
paradigm of inhibitory learning and the acknowledged preclinical model for behavior …

Role of NMDA receptors and MAP kinase in the amygdala in extinction of fear: clinical implications for exposure therapy

M Davis - European Journal of Neuroscience, 2002 - Wiley Online Library
Infusions into the amygdala (a brain area essential for excitatory fear conditioning) of either
NMDA receptor antagonists or inhibitors of the NMDA receptor‐linked mitogen activated …

[HTML][HTML] Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

N Singewald, C Schmuckermair, N Whittle… - Pharmacology & …, 2015 - Elsevier
Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Pharmacological enhancement of fear reduction: preclinical models

BM Graham, JM Langton… - British journal of …, 2011 - Wiley Online Library
Anxiety disorders have a high prevalence, and despite the substantial advances in the
psychological treatment of anxiety, relapse is still a common problem. One approach to …

Facilitation of fear extinction by D-cycloserine: theoretical and clinical implications

R Richardson, L Ledgerwood, J Cranney - Learning & Memory, 2004 - learnmem.cshlp.org
Anxiety disorders are among the most common psychological disturbances in the
industrialized world. Current behavioral therapy procedures for these disorders are …

Extending animal models of fear conditioning to humans

MR Delgado, A Olsson, EA Phelps - Biological psychology, 2006 - Elsevier
A goal of fear and anxiety research is to understand how to treat the potentially devastating
effects of anxiety disorders in humans. Much of this research utilizes classical fear …

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

R Kalisch, B Holt, P Petrovic, B De Martino… - Cerebral …, 2009 - academic.oup.com
Animal research suggests that the consolidation of fear and extinction memories depends
on N-methyl D-aspartate (NMDA)-type glutamate receptors. Using a fear conditioning and …