[PDF][PDF] Cytokine-targeted therapy in severely ill COVID-19 patients: options and cautions

M Rahmati, MA Moosavi - mortality, 2020 - researchgate.net
Dear Editor, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) with the symptoms …

[HTML][HTML] Profile of circulatory cytokines and chemokines in human coronaviruses: a systematic review and meta-analysis

A Zawawi, AY Naser, H Alwafi, F Minshawi - Frontiers in Immunology, 2021 - frontiersin.org
Background SARS, MERS, and COVID-19 share similar characteristics. For instance, the
genetic homology of SARS-CoV-2 compared to SARS-CoV and MERS-CoV is 80% and …

Clinical characteristics and immune injury mechanisms in 71 patients with COVID-19

Y Wu, X Huang, J Sun, T Xie, Y Lei, J Muhammad, X Li… - Msphere, 2020 - Am Soc Microbiol
The outbreak of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a threat to …

[HTML][HTML] Recent insight into SARS-CoV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

S Lega, S Naviglio, S Volpi, A Tommasini - Vaccines, 2020 - mdpi.com
As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great
effort is being made to understand the disease pathogenesis and host factors that …

[HTML][HTML] Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, previously named 2019-nCov), a novel …

[HTML][HTML] SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions

P Asrani, MI Hassan - Molecular and Cellular Biochemistry, 2021 - Springer
The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-
CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and …

[HTML][HTML] Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

Cytokine storm and the prospects for immunotherapy with COVID-19.

LH Calabrese - Cleveland Clinic journal of medicine, 2020 - europepmc.org
Knowledge about the pathobiology of SARS-CoV-2 as it interacts with immune defenses is
limited. SARS-CoV-2 is spread by droplets that come into contact with mucous membranes …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

Understanding COVID-19 pandemic: molecular mechanisms and potential therapeutic strategies. An evidence-based review

R Hanna, S Dalvi, T Sălăgean, ID Pop… - Journal of …, 2021 - Taylor & Francis
Abstract Initially, the SARS-CoV-2 virus was considered as a pneumonia virus; however, a
series of peer reviewed medical papers published in the last eight months suggest that this …